참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydride | HCID 166653 | — |
| 반응물 | 2-(Nitromethylene)imidazolidine | HCID 3014763 | — |
| 반응물 | 2-(Chloromethyl)-5-methylpyrazine | HCID 13221025 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(2-Methyl-5-pyrazinylmethyl)-2-(nitromethylene)imidazolidine | HCID 184600 | 23% |
반응 단계
2-Nitromethyleneimidazolidine (12.9 g) was dissolved in dry dimethylformamide (100 ml), and at room temperature 60% oily soldium hydride (4.4 g) was added. The mixture was stirred at room temperature until the generation of hydrogen ceased. Then, 2-methyl-5-pyrazinylmethyl chloride (14.3 g) was added at room temperature, and the mixture was stirred at 40° C. for 8 hours. After cooling to room temperature, the reaction mixture was added to 200 ml of water, and extracted with dichloromethane. On distilling off dichloromethane from the organic layer under reduced pressure, 1-(2-methyl-5-pyrazinylmethyl)-2-(nitromethylene)imidazolidine (5.4 g) was obtained as yellow crystals having a melting point of 163° to 166° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05428032 |
|---|
| 출처 데이터셋 | uspto-grants-1995_06 |
|---|
| ORD ID | ord-54e0b9c29b3d4d789f270f7885d319b6 |
|---|
| 출처 메모 | uspto-grants-1995_06 |
|---|
