(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol → HCID 22930766, 화합물

HRID 2221612노트

반응식

HRID 2221612 반응식
[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH2:14][OH:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[CH2:1]([O:8][C:9]1[CH:13]=[C:12]([CH:14]=[O:15])[N:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 1

HCID 22930692(3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol

생성물 1

HCID 22930766HCID 22930766, 화합물수율 91%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (3-benzyloxy-1-phenyl-1H-pyrazol-5-yl)methanol (11.20 g), activated manganese dioxide (30.00 g) and tetrahydrofuran (300 mL) was stirred overnight at room temperature. The insoluble material was removed by filtration, and the mother liquid was concentrated. The residue was subjected to silica gel column chromatography to give 3-benzyloxy-1-phenyl-1H-pyrazole-5-carbaldehyde (10.10 g, yield 91%) as a pale-yellow oil from a fraction eluted with ethyl acetate-hexane (1:2, v/v).

후처리

  1. customThe insoluble material was removed by filtration
  2. concentrationthe mother liquid was concentrated

출처 및 근거

ORD 기록
ord-4e3ba7244554440e8361a27aae44d5df
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368578B2

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