(3-amino-1-phenyl-1H-pyrazol-4-yl)methanol → 3-amino-1-phenyl-1H-pyrazole-4-carbaldehyde
반응식
[NH2:1][C:2]1[C:6]([CH2:7][OH:8])=[CH:5][N:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[NH2:1][C:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:3]=1참가 물질
4
실험 절차
A mixture of (3-amino-1-phenyl-1H-pyrazol-4-yl)methanol (12.29 g), activated manganese dioxide (35 g) and tetrahydrofuran (200 mL) was stirred at room temperature for 16 hrs. The reaction mixture was filtered, and the filtrate was concentrated. Recrystallization of the residue from tetrahydrofuran-hexane gave 3-amino-1-phenyl-1H-pyrazole-4-carbaldehyde as pale-yellow crystals (10.02 g, yield 82%). melting point: 129-130° C.
후처리
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customRecrystallization of the residue from tetrahydrofuran-hexane
출처 및 근거
- ORD 기록
- ord-beb7c6aaacdc48baa96767af1f113749
- 출처 데이터셋
- uspto-grants-2008_05
- 특허 번호
- US07368578B2
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