Thionyl Chloride → HCID 23076585, 화합물
반응식
[CH2:1]([N:3]1[CH:7]=[C:6]([CH2:8]O)[N:5]=[CH:4]1)[CH3:2].S(Cl)([Cl:12])=O>O1CCCC1>[ClH:12].[Cl:12][CH2:8][C:6]1[N:5]=[CH:4][N:3]([CH2:1][CH3:2])[CH:7]=1참가 물질
4
실험 절차
To a solution (100 mL) of (1-ethyl-1H-imidazol-4-yl)methanol (5.80 g) in tetrahydrofuran was added thionyl chloride (14.59 g). The reaction mixture was heated under reflux for 1 hr and concentrated. Diethyl ether was added to the residue to allow crystallization, and the obtained crystals were collected by filtration, and washed with diethyl ether. The obtained crystals were recrystallized from methanol-tetrahydrofuran to give 4-chloromethyl-1-ethyl-1H-imidazole hydrochloride as colorless crystals (8.35 g, yield 100%).
후처리
- temperatureThe reaction mixture was heated
- temperatureunder reflux for 1 hr
- concentrationconcentrated
- additionDiethyl ether was added to the residue
- customcrystallization
- filtrationthe obtained crystals were collected by filtration
- washwashed with diethyl ether
- customThe obtained crystals were recrystallized from methanol-tetrahydrofuran
출처 및 근거
- ORD 기록
- ord-09d422aada6a43968ca6a817561fbaf9
- 출처 데이터셋
- uspto-grants-2008_05
- 특허 번호
- US07368578B2
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