Thionyl Chloride → 4-(Chloromethyl)-1-ethyl-1H-pyrazole hydrochloride

HRID 2221661노트

반응식

HRID 2221661 반응식
[CH2:1]([N:3]1[CH:7]=[C:6]([CH2:8]O)[CH:5]=[N:4]1)[CH3:2].S(Cl)([Cl:12])=O>O1CCCC1>[ClH:12].[Cl:12][CH2:8][C:6]1[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[CH:7]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 4711794(1-ethyl-1H-pyrazol-4-yl)methanol

생성물 1

HCID 230765624-(Chloromethyl)-1-ethyl-1H-pyrazole hydrochloride수율 100.2%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution (400 mL) of (1-ethyl-1H-pyrazol-4-yl)methanol (16.80 g) in tetrahydrofuran was added thionyl chloride (40.0 g), and the mixture was stirred at room temperature for 4 hr. The mixture liquid was concentrated under reduced pressure to obtain 4-chloromethyl-1-ethyl-1H-pyrazole hydrochloride as a colorless oil (24.15 g, yield 100%).

후처리

  1. concentrationThe mixture liquid was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-96222216876340cda1bf30403b692e93
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07368578B2

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