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Potassium Carbonate → HCID 69286942, 화합물

HRID 2222201
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인쇄 미리보기

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HRID 2222201 반응식
[F:1][C:2]([F:20])([F:19])[O:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=2)=[CH:6][CH:5]=1.[Cl:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24](Cl)=[O:25].C(=O)([O-])[O-].[K+].[K+]>C1COCC1>[Cl:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[C:24]([N:10]([C:7]1[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:19])[F:20])=[CH:5][CH:6]=1)[C:11]1[S:12][CH:13]=[C:14]([C:16]([OH:18])=[O:17])[N:15]=1)=[O:25]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 691102-Chlorobenzoyl chlorideHCID 336793012-[[4-(Trifluoromethoxy)phenyl]amino]-4-thiazolecarboxylic acid

생성물 1

HCID 69286942HCID 69286942, 화합물수율 72%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
50 °C

실험 절차

A mixture of 2.0 g (6.6 mmol) 2-(4-(trifluoromethoxy)phenylamino)-thiazole-4-carboxylic acid, 2.87 g (16.4 mmol) 2-chlorobenzoyl chloride and 0.92 g (6.6 mmol) potassium carbonate in 50 mL THF was stirred at 50° C. for 48 h. After evaporation of the volatiles the residue was partitioned between water and ethyl acetate. Organic phases were pooled, dried with MgSO4 and the solvent was removed in vacuo. Crystallisation from n-heptane yielded 2.1 g (72%) of the title compound.

후처리

  1. customAfter evaporation of the volatiles the residue
  2. customwas partitioned between water and ethyl acetate
  3. dry with materialdried with MgSO4
  4. customthe solvent was removed in vacuo
  5. customCrystallisation from n-heptane

출처 및 근거

ORD 기록
ord-66a99e55b5334a5597a9f85452a22c38
출처 데이터셋
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07371751B2

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