Hydrazine → HCID 17990173, 화합물

HRID 2222229노트

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HRID 2222229 반응식
Cl[C:2]1[N:7]([CH2:8][CH:9]2[CH2:11][CH2:10]2)[C:6](=[O:12])[NH:5][C:4](=[O:13])[CH:3]=1.[NH2:14][NH2:15]>C(O)C>[CH:9]1([CH2:8][N:7]2[C:2]([NH:14][NH2:15])=[CH:3][C:4](=[O:13])[NH:5][C:6]2=[O:12])[CH2:11][CH2:10]1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 179901746-Chloro-1-cyclopropylmethyluracil

생성물 1

HCID 17990173HCID 17990173, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
82.5 °C

실험 절차

6-Chloro-1-cyclopropylmethyluracil (24.34 g, 0.12 mol) was suspended in absolute ethanol (245 mL) under nitrogen. Anhydrous hydrazine (11.69 g, 0.36 mol) was added via syringe in excess, resulting in a clear-yellow solution. The reaction mixture was heated at 80-85° C. for one hour; bright yellow crystals began forming within minutes of the application of heat. The reaction mixture was cooled to room temperature and then in an ice bath, and the crude product collected by filtration. N2H4×HCl was removed by triturating with cold water to give the product as a pale yellow solid, 20.47 g (86%). Mp 221° C. (dec).

후처리

  1. customresulting in a clear-yellow solution
  2. custombright yellow crystals began forming within minutes of the application
  3. temperatureof heat
  4. temperatureThe reaction mixture was cooled to room temperature
  5. filtrationin an ice bath, and the crude product collected by filtration
  6. customN2H4×HCl was removed
  7. customby triturating with cold water

출처 및 근거

ORD 기록
ord-5eb0f140a6fa4afd9002c08e665fec3b
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371757B2

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