Ethylvanillin → HCID 87761353, 화합물

HRID 2222333노트

반응식

HRID 2222333 반응식
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[OH:12])[CH:7]=[O:8])[CH3:2].[CH3:13][O:14][CH2:15][CH2:16][O:17][CH2:18]Cl>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:11]=1[O:12][CH2:13][O:14][CH2:15][CH2:16][O:17][CH3:18])[CH:7]=[O:8])[CH3:2]

참가 물질

3

반응물 2

HCID 8467EthylvanillinHCID 775901-(Chloromethoxy)-2-methoxyethane

생성물 1

HCID 87761353HCID 87761353, 화합물수율 91.5%

실험 절차

The hydroxyl group of 3-ethoxy-4-hydroxybenzaldehyde (2.0 g) was protected by use of 2-methoxyethoxymethyl chloride (1.5 g) in accordance with (production process 1), to thereby produce 3-ethoxy-4-methoxyethoxymethoxybenzaldehyde (2.8 g, yield: 91%). The thus-produced 3-ethoxy-4-methoxyethoxymethoxybenzaldehyde (2.8 g) and 3,4-dimethoxybenzyl cyanide (2.0 g) were subjected to condensation in accordance with process A of (production process 2), to thereby yield an MEM form of the target product. Subsequently, the protective group was removed from the MEM form in accordance with (production process 3), to thereby produce the target product (1.35 g, yield: 37%).

출처 및 근거

ORD 기록
ord-ef4a11869a9b440f990af35d4f78bf0e
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371773B2

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