Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylenediamine → N-(pyrazinylmethyl)ethylenediamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylenediamine | HCID 3301 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Pyrazine, 2-(chloromethyl)- | HCID 170169 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | N-(pyrazinylmethyl)ethylenediamine | HCID 13910894 | 92.3% |
반응 단계
Ethylenediamine (30 g) was dissolved in acetonitrile (200 ml), and pyrazinylmethyl chloride (12.9 g) was added dropwise to this solution at 5° to 10° C. After addition, the mixture was stirred at room temperature for 1 hour. Then, a 50% aqueous solution of sodium hydroxide (8 g) was added, and thereafter, volatile materials were removed at a bath temperature of 60° C. under 5 mmHg. The inorganic salt was then removed by filtration. Thus, N-(pyrazinylmethyl)ethylenediamine (14.1 g) was obtained as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428032 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-12754f8fb768446eabece947d4a8ee5e |
| 출처 메모 | uspto-grants-1995_06 |