Garenoxacin → HCID 68434103, 화합물

HRID 2222871노트

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HRID 2222871 반응식
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:18]4[CH:19]=[C:20]5[C:24](=[CH:25][CH:26]=4)[C@@H:23]([CH3:27])[NH:22][CH2:21]5)[C:12]=3[O:14][CH:15]([F:17])[F:16])[C:7](=[O:28])[C:6]([C:29]([OH:31])=[O:30])=[CH:5]2)[CH2:3][CH2:2]1>C(O)(=O)C>[C:29]([OH:31])(=[O:30])[CH3:6].[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][CH:10]=[C:11]([C:18]4[CH:19]=[C:20]5[C:24](=[CH:25][CH:26]=4)[C@@H:23]([CH3:27])[NH:22][CH2:21]5)[C:12]=3[O:14][CH:15]([F:17])[F:16])[C:7](=[O:28])[C:6]([C:29]([OH:31])=[O:30])=[CH:5]2)[CH2:3][CH2:2]1

참가 물질

3

반응물 1

HCID 124093Garenoxacin

생성물 1

HCID 68434103HCID 68434103, 화합물수율 84.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

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온도
80 °C

실험 절차

In 0.75 ml of acetic acid is suspended 0.5 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinoline-carboxylic acid and the suspension is warmed to 80° C. to form a uniform solution. Subsequently, the solution is filtered at the same temperature and then 2.5 ml of ethanol is added to the filtrate, after which the crystals deposited are collected by filtration to obtain 0.24 g of (R)-1-cyclopropyl-8-difluoromethoxy-7-(1-methyl-2,3-dihydro-1H-5-isoindolyl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid acetate.

후처리

  1. customto form a uniform solution
  2. filtrationSubsequently, the solution is filtered at the same temperature
  3. addition2.5 ml of ethanol is added to the filtrate
  4. filtrationafter which the crystals deposited are collected by filtration

출처 및 근거

ORD 기록
ord-bdfb654eebf0443696a178a25c4e8908
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07371868B2

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