Potassium Carbonate → HCID 21202762, 화합물

HRID 2223098노트

반응식

HRID 2223098 반응식
[NH:1]1[CH2:11][CH2:10][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:18][O:19][CH2:20][CH2:21]Br>C(O)C>[CH2:8]([O:7][C:5]([CH:4]1[CH2:3][CH2:2][N:1]([CH2:21][CH2:20][O:19][CH3:18])[CH2:11][CH2:10]1)=[O:6])[CH3:9]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 70770Ethyl 4-piperidinecarboxylateHCID 809722-Bromoethyl methyl ether

생성물 1

HCID 21202762HCID 21202762, 화합물수율 92%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A solution of ethyl isonipecotate (26 g, 166 mmol) in ethanol (150 ml) was treated with potassium carbonate (41 g, 297 mmol) and 2-bromoethyl methyl ether (25 g, 179 mmol). After heating at reflux for 24 hours, the mixture was filtered and the solid washed with ethanol. The filtrate was concentrated in vacuo to yield the title compound (32.76 g, 92%); 1H NMR (CDCl3) 4.12 (2H, q, J=7.1 Hz), 3.51 (2H, t, J=5.7 Hz), 3.33 (3H, s), 2.92 (2H, m), 2.56 (2H, t, J=5.7 Hz), 2.33-1.71 (7H, m) and 1.25 (3H, t, J7.1 Hz).

후처리

  1. temperatureAfter heating
  2. temperatureat reflux for 24 hours
  3. filtrationthe mixture was filtered
  4. washthe solid washed with ethanol
  5. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-faa11dca286a42819d4b0eff4f560e88
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07375105B2

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