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Sodium Iodide → 1-{2-[4-(2-Methoxy-phenyl)-piperidin-1-yl]-ethyl}3-(2-methyl-quinolin-4-yl)-urea

HRID 2223705
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HRID 2223705 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.Cl[CH2:16][CH2:17][NH:18][C:19]([NH:21][C:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[N:25]=[CH:24][CH:23]=1)=[O:20].[C:32]([O-])(O)=O.[Na+].[Na+].[I-]>C1COCC1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH2:14][CH2:13][N:12]([CH2:16][CH2:17][NH:18][C:19]([NH:21][C:22]2[C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[N:25]=[C:24]([CH3:32])[CH:23]=2)=[O:20])[CH2:11][CH2:10]1
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참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 516892Sodium BicarbonateHCID 5447384-(2-Methoxyphenyl)piperidineHCID 226433981-(2-Chloroethyl)-3-quinolin-4-yl-urea

생성물 1

HCID 597159221-{2-[4-(2-Methoxy-phenyl)-piperidin-1-yl]-ethyl}3-(2-methyl-quinolin-4-yl)-urea

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

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온도
70 °C

실험 절차

To a solution of 4-(2-methoxy-phenyl)-piperidine (0.03 mmol) in dry THF (1 mL) is added 1-(2-chloro-ethyl)-3-quinolin-4-yl-urea (0.03 mmol), solid NaHCO3 (2.5 mg), and NaI (1 mg). The flask is tightly sealed, and shaken at 70° C. for 6 days. The reaction mixture is evaporated, taken up in aqueous formic acid, and purified by preparative HPLC to provide the title compound.

후처리

  1. customThe flask is tightly sealed
  2. customThe reaction mixture is evaporated
  3. custompurified by preparative HPLC

출처 및 근거

ORD 기록
ord-c0ea3cda6dd04733a0615f3984c9d838
출처 데이터셋
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07375227B2

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