1,3-Bis-(2-methyl-quinolin-4-yl)urea → 4-Benzyl-1-{2-[3-(2-methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid

HRID 2223738노트

반응식

HRID 2223738 반응식
Cl.Cl.[NH2:3][CH2:4][CH2:5][N:6]1[CH2:11][CH2:10][C:9]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([C:12]([OH:14])=[O:13])[CH2:8][CH2:7]1.[CH3:22][C:23]1[CH:32]=[C:31]([NH:33][C:34](NC2C3C(=CC=CC=3)N=C(C)C=2)=[O:35])[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1>C1COCC1>[CH2:15]([C:9]1([C:12]([OH:14])=[O:13])[CH2:10][CH2:11][N:6]([CH2:5][CH2:4][NH:3][C:34]([NH:33][C:31]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:24]=[C:23]([CH3:22])[CH:32]=2)=[O:35])[CH2:7][CH2:8]1)[C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 179565591,3-Bis-(2-methyl-quinolin-4-yl)ureaHCID 692175151-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid dihydrochloride

생성물 1

HCID 179564534-Benzyl-1-{2-[3-(2-methyl-quinolin-4-yl)-ureido]-ethyl}-piperidine-4-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

1-(2-Amino-ethyl)-4-benzyl-piperidine-4-carboxylic acid dihydrochloride (3.35 g, 10 mmol), 1,3-bis-(2-methyl-quinolin-4-yl)-urea (3.43 g, 10 mmol) and TEA (5 mL, 36 mmol) are suspended in THF (50 mL) and heated at reflux for 48 h. The solvent is evaporated and the residue purified by HPLC to provide the title compound.

후처리

  1. temperatureheated
  2. temperatureat reflux for 48 h
  3. customThe solvent is evaporated
  4. customthe residue purified by HPLC

출처 및 근거

ORD 기록
ord-f403d4cbf08949c49d7a3a02604b60f7
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07375227B2

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