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Potassium Carbonate → N-[1-[2-[1-[2-[3,5-Bis(hydroxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide

HRID 2223914
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HRID 2223914 반응식
C([O:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:44][O:45]C(=O)C)[CH:43]=1)[O:9][CH2:10][CH2:11][C:12]1([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([N:26]([C:34]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=3)[C:27]([C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[O:28])[CH2:22][CH2:21]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:4][CH2:5][C:6]1[CH:7]=[C:8]([CH:41]=[C:42]([CH2:44][OH:45])[CH:43]=1)[O:9][CH2:10][CH2:11][C:12]1([CH2:18][CH2:19][N:20]2[CH2:25][CH2:24][CH:23]([N:26]([C:34]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=3)[C:27]([C:29]3[O:30][CH:31]=[CH:32][CH:33]=3)=[O:28])[CH2:22][CH2:21]2)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]1
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HCID 11430Potassium CarbonateHCID 69144599N-[1-[2-[1-[2-[3,5-bis(acetoxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide

생성물 1

HCID 59715008N-[1-[2-[1-[2-[3,5-Bis(hydroxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide수율 94.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-[1-[2-[1-[2-[3,5-bis(acetoxymethyl)phenoxy]ethyl]cyclohexyl]ethyl]piperidin-4-yl]-N-(p-tolyl)-2-furancarboxamide (276 mg) dissolved in methanol (4 mL) was added potassium carbonate (11 mg). The solution was stirred at room temperature for 2 hours. The reaction solution was concentrated under reduced pressure. Saturated aqueous sodium bicarbonate solution was added to the solution, and it was extracted with chloroform-ethanol (80:20). The organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was then concentrated under reduced pressure to give the title compound (228 mg).

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure
  2. additionSaturated aqueous sodium bicarbonate solution was added to the solution, and it
  3. extractionwas extracted with chloroform-ethanol (80:20)
  4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-58a2da11c9734fa59050ab670ba73eb3
출처 데이터셋
uspto-grants-2008_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07375115B2

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