[(3S,6R)-6-(6-azido-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-carbamic acid tert-butyl ester → (3S,6S)-3-amino-6-azido-azepan-2-one

HRID 2224032노트

반응식

HRID 2224032 반응식
C(OC(=O)[NH:7][C@H:8]1[CH2:14][CH2:13][C@H:12]([N:15]=[N+:16]=[N-:17])[CH2:11][NH:10][C:9]1=[O:18])(C)(C)C.C(OC(=O)N[C@H]1CC[C@@H](OCCCCCCN=[N+]=[N-])CN(C)C1=O)(C)(C)C>>[NH2:7][C@H:8]1[CH2:14][CH2:13][C@H:12]([N:15]=[N+:16]=[N-:17])[CH2:11][NH:10][C:9]1=[O:18]

참가 물질

3

반응물 2

HCID 86609579[(3S,6R)-6-(6-azido-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-carbamic acid tert-butyl esterHCID 86609581((3S,6S)-6-azido-2-oxo-azepan-3-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 86609582(3S,6S)-3-amino-6-azido-azepan-2-one

실험 절차

Following the procedure of example 2d) ((3S,6S)-6-azido-2-oxo-azepan-3-yl)-carbamic acid tert-butyl ester is substituted for [(3S,6R)-6-(6-azido-hexyloxy)-1-methyl-2-oxo-azepan-3-yl]-carbamic acid tert-butyl ester to give (3S,6S)-3-amino-6-azido-azepan-2-one. MS (ESI) 170 (M+H)+

출처 및 근거

ORD 기록
ord-104510962f5d4b629f12561a374cd650
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07378410B2

반응 노트

불러오는 중…