Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → (6-Chloro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 2,6-Dichlorobenzoxazole | HCID 77175 | — |
| 반응물 | tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1514454 | — |
| 반응물 | (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine | HCID 59178006 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (6-Chloro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride | HCID 131728778 | — |
반응 단계
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine; hydrochloride (example 1, step 2) the title compound was prepared from (S)-3-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester and 2,6-dichloro-benzooxazole (commercially available) and subsequent cleavage of the tert-butyloxy carbonyl-protecting group through treatment with HCl in dioxane. MS (m/e): 252.2 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207220B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-9d0366cd428f464a9f92da35da2bfa66 |
| 출처 메모 | uspto-grants-2012_06 |