(2,6-Dichloropyridin-3-yl)methanol → 3-(Bromomethyl)-2,6-dichloropyridine

반응식

ClC1C(CO)=CC=C(Cl)N=1.[Br:11][CH2:12][C:13]1[C:14]([Cl:21])=[N:15][C:16]([Cl:20])=[C:17](F)[CH:18]=1>>[Br:11][CH2:12][C:13]1[C:14]([Cl:21])=[N:15][C:16]([Cl:20])=[CH:17][CH:18]=1

참가 물질

반응물 2

HCID 12259932(2,6-Dichloropyridin-3-yl)methanol

HCID 597175733-(Bromomethyl)-2,6-dichloro-5-fluoropyridine

생성물 1

HCID 122653943-(Bromomethyl)-2,6-dichloropyridine수율 80%

실험 절차

Compound 13B (0.88 g, 80%) was prepared from 13A (0.82 g, 4.6 mmol) using a procedure similar to the synthesis of 1B. HPLC Rt=2.44 min.

출처 및 근거

ORD 기록: ord-1c1b1d9f2abd4e32abc23d47397accaf
출처 데이터셋: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07378426B2

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