Tert-Butyl nitrite → 3,5-Dibromo-2-methylpyridine

HRID 2224348

반응식

HRID 2224348 반응식
[Br:1][C:2]1[C:3](N)=[N:4][C:5]([CH3:9])=[C:6]([Br:8])[CH:7]=1.C(ON=O)(C)(C)C>C1COCC1>[Br:8][C:6]1[C:5]([CH3:9])=[N:4][CH:3]=[C:2]([Br:1])[CH:7]=1

참가 물질

4

반응물 2

HCID 10906Tert-Butyl nitriteHCID 522994Wisteria sinensis, ext.

생성물 1

HCID 6197053,5-Dibromo-2-methylpyridine수율 42.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 3,5-dibromo-6-methyl-pyridin-2-ylamine (2.0 g, 7.5 mmol) in THF (75 mL) was added t-butylnitrite (1.5 mL, 12.6 mmol) and the reaction was heated to reflux for 2 hours. The reaction was concentrated in vacuo and purified by flash chromatography (SiO2, CH2Cl2) to give 52A (0.8 g 42%). HPLC Rt=2.77 min.

후처리

  1. temperaturethe reaction was heated
  2. temperatureto reflux for 2 hours
  3. concentrationThe reaction was concentrated in vacuo
  4. custompurified by flash chromatography (SiO2, CH2Cl2)

출처 및 근거

ORD 기록
ord-047d0d3583784aa993554947dd91ce01
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07378426B2

연결된 노트

불러오는 중…