N-(2-Chloro-5-iodo-pyridin-4-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide → 6-Acetyl-3,9-dichloro-5,6-dihydropyrido[4,3-c][1]benzazocine

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][N:9]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=2[CH:20]=[CH2:21])[C:10](=[O:12])[CH3:11])[C:5](I)=[CH:4][N:3]=1.C(N1C2C=CC=CC=2C=CC2N=C(Cl)C(F)=CC=2C1)(=O)C>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[CH:21]=[CH:20][C:14]3[CH:15]=[C:16]([Cl:19])[CH:17]=[CH:18][C:13]=3[N:9]([C:10](=[O:12])[CH3:11])[CH2:8][C:6]=2[CH:7]=1

참가 물질

반응물 2

HCID 59717576N-(2-Chloro-5-iodo-pyridin-4-ylmethyl)-N-(4-chloro-2-vinyl-phenyl)-acetamide

HCID 743934126-Acetyl-2-chloro-3-fluoro-5,6-dihydro-pyrido[3,2-c][1]benzazocine

생성물 1

HCID 723667806-Acetyl-3,9-dichloro-5,6-dihydropyrido[4,3-c][1]benzazocine수율 73%

실험 절차

Compound 77C (26 mg, 73%) was prepared from 77B (50 mg, 0.13 mmol) by a route analogous to that used for the preparation of 1D.

출처 및 근거

ORD 기록: ord-865e9a2daf1748cdab605f7e10890442
출처 데이터셋: uspto-grants-2008_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07378426B2

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