Methyl 2-allyl-2-phenyl-4-pentenoate → Methyl 2-phenyl-2-propylpentanoate

HRID 2224755노트

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HRID 2224755 반응식
[CH2:1]([C:4]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH2:9][CH:10]=[CH2:11])[C:5]([O:7][CH3:8])=[O:6])[CH:2]=[CH2:3]>C(OCC)(=O)C.[Pd]>[C:12]1([C:4]([CH2:9][CH2:10][CH3:11])([CH2:1][CH2:2][CH3:3])[C:5]([O:7][CH3:8])=[O:6])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

4

반응물 1

HCID 11085592Methyl 2-allyl-2-phenyl-4-pentenoate

생성물 1

HCID 11658708Methyl 2-phenyl-2-propylpentanoate수율 100%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

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온도
25 °C

실험 절차

A solution of the product of Example 1A (7.5 g, 32.61 mmol) in ethyl acetate (125 mL) was treated with 10% palladium on carbon (600 mg) and stirred at 25° C. under hydrogen gas for 18 hours. The solution was filtered through celite® and the filtrate was concentrated in vacuo to give the title compound (7.63 g, 100%). 1H NMR (300 MHz, CDCl3): δ 7.27 (m, 5 H), 3.64 (m, 3 H), 1.96 (m, 4 H), 1.08 (m, 4 H), 0.89 (t, J=7.17 Hz, 6 H).

후처리

  1. filtrationThe solution was filtered through celite®
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-4fc131bde7df4376bc154572b484ac53
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07378414B2

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