Thionyl Chloride → 4-(Chloromethyl)-5-methyl-2-(4-methylphenyl)-1,3-oxazole

HRID 22250노트

반응식

HRID 22250 반응식
O[CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8].S(Cl)([Cl:18])=O>ClCCl>[Cl:18][CH2:2][C:3]1[N:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=2)[O:6][C:7]=1[CH3:8]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 19430222HCID 19430222, 화합물

생성물 1

HCID 50764854-(Chloromethyl)-5-methyl-2-(4-methylphenyl)-1,3-oxazole

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 4-hydroxymethyl-2-(4-methylphenyl)-5-methyl-1,3-oxazole (3 g) in 30 ml of dichloromethane was cooled to 0° C., and thionyl chloride (1.75 g) added dropwise. The reaction was stirred for 1 hour at room temperature, then washed twice with dilute sodium bicarbonate solution, the organic layer separated, dried over sodium sulfate, and the solvent evaporated under reduced pressure, to yield 4-chloromethyl-2-(4-methylphenyl)-5-methyl-l,3-oxazole, which was used in the next reaction without further purification.

후처리

  1. washwashed twice with dilute sodium bicarbonate solution
  2. customthe organic layer separated
  3. dry with materialdried over sodium sulfate
  4. customthe solvent evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-907e8a3271eb451eb04e801c9d881b52
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428037

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