Thionyl Chloride → 4-Benzoylamino-naphthalene-1-sulfonyl chloride

HRID 2225067

반응식

HRID 2225067 반응식
[C:1]([NH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([S:20]([OH:23])(=O)=[O:21])=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:26])=O>CN(C=O)C>[C:1]([NH:9][C:10]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([S:20]([Cl:26])(=[O:23])=[O:21])=[CH:12][CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 35301064-Benzoylamino-naphthalene-1-sulfonic acid

생성물 1

HCID 161057574-Benzoylamino-naphthalene-1-sulfonyl chloride수율 88.2%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of the pyridinium salt of 4-benzoylamino-napthalene-1-sulfonic acid (2.4 g, 5.9 mmol) in DMF (10 mL), was added thionyl chloride (0.6 mL, 8.8 mmol). The resultant solution was stirred at 25° C. for 3 hours. The reaction mixture was quenched by pouring into ice water and filtered to give the title compound (1.8 g) a pale white solid. This material was used without further purification.1H NMR (300 MHz, DMSO) δ 8.88 (d, 1H), 8.09 (d, 2H), 7.97 (d, 2H), 7.55 (m, 6H).

후처리

  1. customThe reaction mixture was quenched
  2. additionby pouring into ice water
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-61ba3e93bb3f4265a0d1159913782f44
출처 데이터셋
uspto-grants-2008_05
특허 번호
US07378525B2

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