Trifluoroacetic acid → (s)-n-{(s)-1-Cyclohexyl-2-oxo-2-[(s)-2-(3-phenoxy-phenyl)-pyrrolidin-1-yl]-ethyl}-2-methylamino-propionamide

HRID 222507노트

반응식

HRID 222507 반응식
C(O[C:6](=O)[N:7]([C@H:9]([C:11](=[O:40])[NH:12][C@@H:13]([CH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1)[C:14](=[O:33])[N:15]1[CH2:19][CH2:18][CH2:17][C@H:16]1[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=1)[CH3:10])C)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:34]1([C@H:13]([NH:12][C:11](=[O:40])[C@@H:9]([NH:7][CH3:6])[CH3:10])[C:14](=[O:33])[N:15]2[CH2:19][CH2:18][CH2:17][C@H:16]2[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[CH:21]=2)[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 67003947((S)-1-{(S)-1-Cyclohexyl-2-oxo-2-[(S)-2-(3-phenoxy-phenyl)-pyrrolidin-1-yl]-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester

생성물 1

HCID 54669904(s)-n-{(s)-1-Cyclohexyl-2-oxo-2-[(s)-2-(3-phenoxy-phenyl)-pyrrolidin-1-yl]-ethyl}-2-methylamino-propionamide수율 101%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of ((S) 1-{(S)-1-cyclohexyl-2-oxo-2-[(S)-2-(3-phenoxy-phenyl)-pyrrolodin-1-yl]-ethylcarbamoyl}-ethyl)-methyl-carbamic acid tert-butyl ester (450 mgs, 0.79 mmol) in CH2Cl2 (20 mL) is added TFA (10 mL) and stirred for 30 minutes. The mixture is concentrated under reduced pressures and purified by reverse phase column chromatography to give the product as a TFA salt (370 mgs, 82%). LCMS m/z 464.1 (M+1).

후처리

  1. concentrationThe mixture is concentrated under reduced pressures
  2. custompurified by reverse phase column chromatography

출처 및 근거

ORD 기록
ord-7597882d5338495e94060dcb1eca96e1
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207183B2

반응 노트

불러오는 중…