참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Malonic Acid | HCID 867 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 2-Aminobenzaldehyde | HCID 68255 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 2-Quinolone-3-carboxylic acid | HCID 332488 | — |
반응 단계
2 Grams of malonic acid was dissolved in 15 ml of pyridine, then 1.2 g of o-aminobenzaldehyde and 2 ml of piperidine were added thereto, and the mixture was stirred at 90° C. for 5 hours. The reaction mixture was poured in an aqueous solution of hydrochloric acid and the crystals precipitated were collected by filtration. Recrystallized from methanol-chloroform to obtain 1.2 g of 3-carboxycarbostyril in the form of colorless needle-like crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | USRE034722 |
|---|
| 출처 데이터셋 | uspto-grants-1994_09 |
|---|
| ORD ID | ord-e9275bd61d724c5faffa0e0519491c3e |
|---|
| 출처 메모 | uspto-grants-1994_09 |
|---|
