Amoxapine → Ethyl 4-(2-Chlorodibenz[b,f][1,4]oxazepin-11-yl)-1-piperazinepropionate

HRID 2225362

반응식

HRID 2225362 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]3)[C:6]=2[CH:22]=1.[C:23]([O:27][CH2:28][CH3:29])(=[O:26])[CH:24]=[CH2:25]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=[C:7]([N:16]3[CH2:21][CH2:20][N:19]([CH2:25][CH2:24][C:23]([O:27][CH2:28][CH3:29])=[O:26])[CH2:18][CH2:17]3)[C:6]=2[CH:22]=1

참가 물질

4

반응물 2

HCID 2170AmoxapineHCID 8821Ethyl Acrylate

생성물 1

HCID 19004099Ethyl 4-(2-Chlorodibenz[b,f][1,4]oxazepin-11-yl)-1-piperazinepropionate수율 88.8%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 3.14 g of 2-chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine and 1.20 g of ethyl acrylate in 16 ml of ethanol was refluxed for 2 hrs. The reaction mixture was concentrated and the residue was chromatographed on silica gel using a mixture of n-hexane and ethyl acetate (2:1 and 1:1) as eluents to give 3.68 g of yellow crystals, which were recrystallized from a mixture of isopropyl ether and n-pentane to give yellow prisms, mp 73°-75° C.

후처리

  1. temperaturewas refluxed for 2 hrs
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was chromatographed on silica gel using
  4. additiona mixture of n-hexane and ethyl acetate (2:1 and 1:1) as eluents

출처 및 근거

ORD 기록
ord-4359d8848c7d4e5288d82b7beea1df2c
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344828

연결된 노트

불러오는 중…