2,5-Dichlorobenzenesulfonyl chloride → 3-(2,5-Dichlorobenzenesulfonamido)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

HRID 2225450

반응식

HRID 2225450 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:18])([CH2:16][NH2:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[S:27](Cl)(=[O:29])=[O:28]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][C:21]=1[S:27]([NH:17][CH2:16][C:9]([C:3]1[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=1[Cl:1])([OH:18])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1)(=[O:29])=[O:28]

참가 물질

3

반응물 2

HCID 794012,5-Dichlorobenzenesulfonyl chlorideHCID 147065211-[3-Amino-2-(2,4-dichlorophenyl)-2-hydroxyprop-1-yl]-1H-1,2,4-triazole

생성물 1

HCID 189579793-(2,5-Dichlorobenzenesulfonamido)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)propan-2-ol

실험 절차

Following the procedure described in the preceeding examples but using 2-(2,4-dichlorophenyl)-3-amino-1-(1H-1,2,4-triazol-1-yl)propan-2-ol and 2,5-dichlorobenzenesulfonylchloride, the title compound was obtained in a similar yield: mp 173°-174° C.; 1H NMR (80 MHz, CDCl3)δ(TMS) 8.05 (s, 1H, CH=N), 7.78 (s, 1H, CH=N), 8.0-7.0 (m, 6H, arom), 4.89 (AB system, Δv=0.42, J=14.5 Hz, 2H, CH2 -Tr), 3.87 (AB system, Δv=0.30, J=14 Hz, 2H, CH2NH). Anal calcd. for C17H14C14N4O3S: C 41.15%; H 2.84%; N 11.29%. Found: C 40.86%; H 3.06%; N 11.28%.

출처 및 근거

ORD 기록
ord-5c25d5b388184a67bad63b6585452be8
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344839

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