HCID 178418361, 화합물 → HCID 178490507, 화합물

HRID 2225521

반응식

HRID 2225521 반응식
[CH3:1][N:2]([CH3:28])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]([C@H:21]1[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]1)[C:8](=[O:20])[CH:9]=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=1.[H][H]>CO.[C].[Pd]>[CH3:28][N:2]([CH3:1])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]([C@H:21]1[CH2:26][CH2:25][C@H:24]([CH3:27])[CH2:23][CH2:22]1)[C:8](=[O:20])[CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([O:18][CH3:19])[CH:12]=1

참가 물질

5

반응물 2

HCID 178418361HCID 178418361, 화합물HCID 178490506HCID 178490506, 화합물

생성물 1

HCID 178490507HCID 178490507, 화합물수율 91.5%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

0.05 g of 10% palladium-carbon was added to a solution of 1 g of N-(4-dimethylaminobutyl)-N-(trans-4-methylcyclohexyl)-4-hydroxy-3-methoxycinnamamide (Example 75) in 60 ml of methanol. Under normal-pressure hydrogen gas, the solution was reacted for 16 hours, while it was vigorously stirred. After reaction, the catalyst was filtered out, and the solvent was removed in vacuo from the filtrate, yielding 0.92 g of N-(4-dimethylaminobutyl)-N-(trans-4-methylcyclohexyl)-3-(4-hydroxy-3-methoxyphenyl)propionamide (a compound of the present invention) as a pale yellow oily oil, which had the following physiochemical properties:

후처리

  1. customAfter reaction
  2. filtrationthe catalyst was filtered out
  3. customthe solvent was removed in vacuo from the filtrate

출처 및 근거

ORD 기록
ord-7fad1ad9d1ee4eabac525e294b0ab22a
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344845

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