Potassium Hydroxide → 2-(p-Fluorophenyl)-6-isopropylphenol

HRID 2225796노트

반응식

HRID 2225796 반응식
C([O:3][C:4]1[C:5]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[CH:6][CH:7]=[CH:8][C:9]=1[CH:10]([CH3:12])[CH3:11])=O.[OH-].[K+]>C(O)C>[F:19][C:16]1[CH:15]=[CH:14][C:13]([C:5]2[C:4]([OH:3])=[C:9]([CH:10]([CH3:11])[CH3:12])[CH:8]=[CH:7][CH:6]=2)=[CH:18][CH:17]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 190043884'-Fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-ol formate

생성물 1

HCID 146639662-(p-Fluorophenyl)-6-isopropylphenol수율 106.6%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

To a solution of 4'-fluoro-3-(1-methylethyl)[1,1'-biphenyl]-2-ol formate (2 g) in ethanol (5 mL) was added a 10% solution of potassium hydroxide in ethanol (10 mL) and the reaction mixture was stirred at room temperature for 1 hour. The reaction was concentrated in vacuo, and the residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL). The separated aqueous layer was extracted with dichloromethane (2×20 mL), then the combined organic layers were washed with water, dried (MgSO4) and evaporated to furnish 1.9 g of 4'-fluoro-3-(1-methylethyl) [1,1'-biphenyl]-2-ol as a oil which solidified on standing. A small sample was sublimed to give the analytical specimen, mp 41°-43° C.

후처리

  1. concentrationThe reaction was concentrated in vacuo
  2. customthe residue was partitioned between dichloromethane (20 mL) and 1N hydrochloric acid (20 mL)
  3. extractionThe separated aqueous layer was extracted with dichloromethane (2×20 mL)
  4. washthe combined organic layers were washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-b3e9641edba9470eaa510319c6aa4b2b
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344843

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