Water → HCID 19004319, 화합물

HRID 2225815노트

반응식

HRID 2225815 반응식
[Br:1][CH2:2][C:3](Cl)=[O:4].[F:6][C:7]([F:23])([F:22])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1.O>ClCCl>[Br:1][CH2:2][C:3]([N:19]1[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7]([F:22])([F:23])[F:6])[CH2:21][CH2:20]1)=[O:4]

참가 물질

5

반응물 3

HCID 962WaterHCID 89602Bromoacetyl chlorideHCID 30233251-[2-(trifluoromethyl)phenethyl]piperazine

생성물 1

HCID 19004319HCID 19004319, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Bromoacetyl chloride (0.125 mL) was added slowly to a chilled (5 ° C.) solution of 1-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine (0.774 g) in dichloromethane (20 mL) and the mixture was stirred in an ice bath for 45 minutes, then at room temperature for 18 hours. After the addition of water (20 mL), the organic layer was separated and washed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution. The dried (MgSO4) extract was evaporated to give 0.5 g of 1-(2-bromo-1-oxoethyl)-4-[2-[2-(trifluoromethyl)phenyl]ethyl]piperazine.

후처리

  1. waitat room temperature for 18 hours
  2. customthe organic layer was separated
  3. washwashed in turn with 0.5N hydrochloric acid and sodium bicarbonate solution
  4. dry with materialThe dried (MgSO4)
  5. extractionextract
  6. customwas evaporated

출처 및 근거

ORD 기록
ord-e122b200a7934759ba9a1ebb41fb5c15
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344843

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