Methanol → 2-methyl-1-[4-[[6-(1-methylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-3-pyridyl]oxymethyl]-1-piperidyl]propan-2-ol

참여 물질

반응 단계

4-(1′-Methanesulfonyl-1′,2′,3′,6′-tetrahydro-[2,4′]bipyridinyl-5-yloxymethyl)-piperidine is suspended in 800 mL of methanol and added to an autoclave with a mechanical stirrer. 1500 mL of methanol are added and then dimethyloxirane (117 g, 1.62 mol) is added. The mixture is stirred at 60˜70° C. for 88 h, cooled to 25˜30° C. and concentrated to 1000 mL. The mixture is heated at 60˜70° C. and 4200 mL of water are added. The resulting mixture is stirred at 60˜70° C. during 30 min and cooled slowly to 0˜5° C. in 1.5˜2 h. It is stirred at this temperature for 30 minutes and filtered. The cake is slurried with H2O: MeOH=3:1 (600 mL) pre-cooled to 0˜5° C. and concentrated (2×). The product is dried under vacuum at 40˜50° C. to provide 320 g of off-white solid with 98.3% HPLC purity.

출처 및 근거