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N-methylhydroxylamine hydrochloride → HCID 19004271, 화합물

HRID 2225853
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인쇄 미리보기

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HRID 2225853 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:25])[C:22](Cl)=[O:23])=[CH:17][CH:16]=1.C1C2C(=CC=CC=2)C=CC=1OCCOC1C=CC(C(=O)C(O)=O)=CC=1.Cl.[CH3:52][NH:53][OH:54]>ClCCl.N1C=CC=CC=1.O>[OH:54][N:53]([CH3:52])[C:22](=[O:23])[C:21](=[O:25])[C:18]1[CH:19]=[CH:20][C:15]([O:14][CH2:13][CH2:12][O:11][C:2]2[CH:3]=[CH:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH:1]=2)=[CH:16][CH:17]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 77906N-methylhydroxylamine hydrochlorideHCID 19004267HCID 19004267, 화합물HCID 19004394HCID 19004394, 화합물

생성물 1

HCID 19004271HCID 19004271, 화합물

시약·촉매·용매 3

HCID 962Water용매HCID 1049Pyridine용매
HCID 6344
Dichloromethane
용매

실험 절차

A solution of 4-[2-(2-naphthalenyloxy)ethoxy]-alpha-oxobenzeneacetyl chloride, derived from 4-[2-(2-naphthalenyloxy)ethoxy]-alpha-oxobenzeneacetic acid (0.312 g) in the previously described manner (Example 6), in dichloromethane was treated with a solution of N-methylhydroxylamine hydrochloride (0.094 g) in pyridine (1.5 mL). After the reaction solution was stirred at room temperature for 18 hours, it was concentated in vacuo and then diluted with water. The resulting fine yellow precipitate was filtered off, dried and crystallized from methanol-water to afford 0.129 g of N-hydroxy-N-methyl-4-[2-(2-naphthalenyloxy)ethoxy]-alpha-oxobenzeneacetamide, mp 161°-165° C.

후처리

  1. filtrationThe resulting fine yellow precipitate was filtered off
  2. customdried
  3. customcrystallized from methanol-water

출처 및 근거

ORD 기록
ord-b78eb82d4324418585a94c89a4df28bf
출처 데이터셋
uspto-grants-1994_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05344843

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