Tetrabutylammonium Fluoride → HCID 178418635, 화합물

HRID 2226016

반응식

HRID 2226016 반응식
C[Si]([C:5]#[C:6][N:7]1[C:12]([OH:13])=[C:11]2[CH:14]=[C:15]([NH:17][C:18](=[O:23])[C:19]([CH3:22])([CH3:21])[CH3:20])[N:16]=[C:10]2[N:9]=[CH:8]1)(C)C.[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[C:6]([N:7]1[C:12]([OH:13])=[C:11]2[CH:14]=[C:15]([NH:17][C:18](=[O:23])[C:19]([CH3:21])([CH3:20])[CH3:22])[N:16]=[C:10]2[N:9]=[CH:8]1)#[CH:5]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 178418686HCID 178418686, 화합물

생성물 1

HCID 178418635HCID 178418635, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 1.5 g of 3-trimethylsilylethynyl-4-hydroxy-6-pivaloylaminopyrrolo[2,3-d]pyrimidine in 100 mL of anhydrous tetrahydrofuran cooled to 0° C. are added under nitrogen 4.75 mL of 1M tetrabutylammonium fluoride in anhydrous tetrahydrofuran. After 5 minutes, the reaction mixture is allowed to attain room temperature and is then stirred for 2 hours. The solvent is removed under reduced pressure and the residue purified by chromatography over silica gel to yield 3-ethynyl-4-hydroxy-6-pivaloylaminopyrrolo[2,3-d]pyrimidine.

후처리

  1. customto attain room temperature
  2. customThe solvent is removed under reduced pressure
  3. customthe residue purified by chromatography over silica gel

출처 및 근거

ORD 기록
ord-17e3de88c2ae4027a32974bee729ee29
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05344932

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