Potassium Hydroxide → HCID 54288038, 화합물

HRID 2226176노트

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HRID 2226176 반응식
[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:13])([CH3:12])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[C:15][Si](C)(C)C)=[CH:7][CH:8]=2)[O:3]1.[OH-].[K+]>C(O)(C)C>[CH3:1][C:2]1([CH3:20])[CH2:11][C:10]([CH3:12])([CH3:13])[C:9]2[C:4](=[CH:5][C:6]([C:14]#[CH:15])=[CH:7][CH:8]=2)[O:3]1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 189663522,2,4,4-Tetramethyl-7-trimethylsilylethynyl-chroman2회

생성물 1

HCID 54288038HCID 54288038, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a solution of 1.16 g (4.1 mmol) of 2,2,4,4-tetramethyl-7-trimethylsilylethynyl-chroman (Compound 43) in 3 ml of isopropanol was added 5 ml of ethanolic KOH solution. The reaction mixture was stirred at room temperature for 24 hours and the alcohol was then removed under vacuum. The residue was extracted with 2×10 ml of ether and the combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution and then dried (MgSO4). The solvent was removed in vacuo and the residue purified by Kugelrohr distillation to give the title compound as a white crystalline solid.

후처리

  1. customthe alcohol was then removed under vacuum
  2. extractionThe residue was extracted with 2×10 ml of ether
  3. washthe combined ether extracts were washed with 15 ml of water and 20 ml of saturated NaCl solution
  4. dry with materialdried (MgSO4)
  5. customThe solvent was removed in vacuo
  6. distillationthe residue purified by Kugelrohr distillation

출처 및 근거

ORD 기록
ord-d93039f70b704a81b647a62bc6729938
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05346915

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