(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane → (+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

HRID 2226189노트

반응식

HRID 2226189 반응식
[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH3:7][O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH:12]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]3([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)[CH2:26][C:25]1=[O:35])[CH2:13][O:14]2.CO[C:38]1[CH:47]=CC=C2[C:39]=1CC(NCCCCN1C(=O)C3(CCCCC3)CC1=O)CO2>>[C:1]([OH:6])(=[O:5])[C:2]([OH:4])=[O:3].[CH2:39]([N:19]([CH2:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2([CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[CH2:26][C:25]1=[O:35])[CH:12]1[CH2:11][C:10]2[C:15](=[CH:16][CH:17]=[CH:18][C:9]=2[O:8][CH3:7])[O:14][CH2:13]1)[CH2:38][CH3:47]

참가 물질

3

반응물 2

HCID 18966575(+)-3-[4-[N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]DecaneHCID 18966585(+)-3-{4-[N-(5-Methoxy-3-Chromanyl)Amino]Butyl}-2,4-Dioxo-3-Azaspiro[4.5]Decane Oxalate

생성물 1

HCID 18966570(+)-3-[4-[N-n-Propyl-N-(5-Methoxychroman-3-Yl)Amino]Butyl]-2,4-Dioxo-3-Azaspiro[4.5]Decane (Oxalate)

실험 절차

Using the procedure described in Example 29, but replacing the compound of Example 28 by the compound of Example 30, the product of the title is obtained.

후처리

  1. customthe product of the title is obtained

출처 및 근거

ORD 기록
ord-49b87e04ab7340c8964939a420b85ca1
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05346916

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