Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium cyanoborohydride → N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | N,N-diethyl-5-phenyl-5-hydroxy-3-oxopentanamide | HCID 18967271 | — |
| 촉매 | Chlorotitanium triisopropoxide | HCID 3084342 | — |
| 생성물 | N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide | HCID 19003821 | 70.2% |
반응 단계
By carrying out the reaction as in Example 9 but starting from 1.02 g of N,N-diethyl-5-phenyl-5-hydroxy-3-oxopentanamide (3.92 mmol), 1.05 cm3 of titanium chloride triisopropoxide (4.18 mmol) and from 283.9 mg of sodium cyanoborohydride (4.28 mmol), there is obtained, with a yield of 70.2%, 730 mg of N,N-diethyl-5-phenyl-3,5-dihydroxypentanamide for which the syn/anti ratio is equal to 80/20.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05347039 |
| 출처 데이터셋 | uspto-grants-1994_09 |
| ORD ID | ord-a279125cc388433fadb42102b4837784 |
| 출처 메모 | uspto-grants-1994_09 |