참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Piperidine, 1-(2-chloroethyl)-, hydrochloride | HCID 74826 | — |
| 반응물 | Bis(2-amino-1H-imidazole) sulphate | HCID 135136 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(2-(Piperidin-1-YL)ethyl)-1H-imidazol-2-amine | HCID 53402474 | 22.6% |
반응 단계
2-Aminoimidazole monosulfate (500 mg, 1.89 mmol) and potassium carbonate (580 mg, 4.16 mmol) were suspended in DMF (2 mL) and chloroethyl piperidine mono hydrochloride (766 mg, 4.16 mmol) was added. The reaction was heated at 100° C. for 2.5 hours before being cooled to room temperature and filtered. The filtrate was concentrated and purified by column chromatography (95:4.5:0.5 dichloromethane:methanol:aqueous ammonia) and the product was isolated as a brown oil (83 mg, 11%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08207334B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_06 |
|---|
| ORD ID | ord-5a74d01fdcd14d459f877a5ccbc1b94d |
|---|
| 출처 메모 | uspto-grants-2012_06 |
|---|
