Dicyclohexylcarbodiimide → HCID 178444511, 화합물

HRID 2226345노트

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HRID 2226345 반응식
C1(N=C=NC2CCCCC2)CCCCC1.[F:16][C:17]([F:29])([C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[CH:24][CH:23]=1)[C:18]([F:21])([F:20])[F:19].[CH2:30]([C@H:35]1[CH2:40][CH2:39][C@H:38]([C@H:41]2[CH2:46][CH2:45][C@H:44]([C:47](O)=[O:48])[CH2:43][CH2:42]2)[CH2:37][CH2:36]1)[CH2:31][CH2:32][CH2:33][CH3:34].CN(C1C=CC=CN=1)C>C(Cl)Cl>[CH2:30]([C@H:35]1[CH2:40][CH2:39][C@H:38]([C@H:41]2[CH2:42][CH2:43][C@H:44]([C:47]([O:28][C:25]3[CH:26]=[CH:27][C:22]([C:17]([F:29])([F:16])[C:18]([F:20])([F:19])[F:21])=[CH:23][CH:24]=3)=[O:48])[CH2:45][CH2:46]2)[CH2:37][CH2:36]1)[CH2:31][CH2:32][CH2:33][CH3:34]

참가 물질

6

반응물 4

HCID 10868DicyclohexylcarbodiimideHCID 218852-DimethylaminopyridineHCID 10856782Phenol, 4-(pentafluoroethyl)-HCID 178444515HCID 178444515, 화합물

생성물 1

HCID 178444511HCID 178444511, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

0.1 mol of dicyclohexylcarbodiimide (DCC) in 30 ml of CH2Cl2 is added with stirring at about 10° to a mixture of 0.1 mol of 4-(pentafluoroethyl)-phenol (preparation analogously to Bull. Chem. Soc. Japan, 57 (1984) 3361), 0.1 mol of trans-4-(trans-4-pentylcyclohexyl)cyclohexanecarboxylic acid and 0.01 mol of dimethylaminopyridine and 150 ml of CH2Cl2, and the mixture is then stirred for 15 hours at room temperature. It is filtered over silica gel, the solvent is evaporated and further purification gives 4-(pentafluoroethyl)-phenyl trans-4-(trans-4-pentylcyclohexyl)-cyclohexanoate.

후처리

  1. custompreparation analogously to Bull
  2. filtrationIt is filtered over silica gel
  3. customthe solvent is evaporated
  4. customfurther purification

출처 및 근거

ORD 기록
ord-4b721be911454b8394fc862384a86585
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05348677

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