m-Chloroperbenzoic acid → 1-(2-Chloroethanesulfinyl)heptane

HRID 2226471노트

반응식

HRID 2226471 반응식
[CH2:1]([S:8][CH2:9][CH2:10][Cl:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].ClC1C=CC=C(C(OO)=[O:20])C=1.S(S([O-])=O)([O-])(=O)=O.[Na+].[Na+].C(=O)([O-])O.[Na+]>C(Cl)Cl>[CH2:1]([S:8]([CH2:9][CH2:10][Cl:11])=[O:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

6

반응물 4

HCID 70297m-Chloroperbenzoic acidHCID 3043712-Chloroethyl heptyl sulfideHCID 516892Sodium BicarbonateHCID 656671Sodium Pyrosulfite

생성물 1

HCID 3043751-(2-Chloroethanesulfinyl)heptane수율 111%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-20 °C

실험 절차

Dissolve 2-chloroethyl heptyl sulfide (1.0 g, 5.13 mmol) in methylene chloride (50 mL), cool to -20° C. and place under nitrogen atmosphere. Add, by dropwise addition, a solution of meta-chlorperbenzoic acid (1.25 g, 6.0 mmol) in methylene chloride. Stir at -20° C. for 3 hours, then allow to warm to room temperature. Treat with saturated sodium meta bisulfite (until negative starch-iodide test) and basify with saturated sodium hydrogen carbonate. Extract with methylene chloride (2×25 mL), dry (MgSO4) and evaporate in vacuo to yield 1.2 g of 2chloroethyl heptyl sulfoxide as white crystals; MS (CI/CH4) m/z 211(M+1).

후처리

  1. additionAdd, by dropwise addition
  2. temperatureto warm to room temperature
  3. extractionExtract with methylene chloride (2×25 mL)
  4. dry with materialdry (MgSO4)
  5. customevaporate in vacuo

출처 및 근거

ORD 기록
ord-3c2c937d1f2f4d95872e7a88d37dee74
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05348964

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