Morpholine → 4-(6-Chloropyridine-3-carbonyl)morpholine

HRID 222651노트

반응식

HRID 222651 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][N:9]=1>ClCCl>[Cl:7][C:8]1[N:9]=[CH:10][C:11]([C:12]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)=[O:13])=[CH:15][CH:16]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 27821656-Chloronicotinoyl Chloride

생성물 1

HCID 8574994-(6-Chloropyridine-3-carbonyl)morpholine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Morpholine (0.2 ml, 2.2 mmol) was added to stirred solution of 6-chloronicotinoyl chloride (250 mg, 1.4 mmol) in dichloromethane (10 ml). After 2 hours the reaction was allowed to cool and the crude mixture was applied to a SCX ion exchange cartridge (Varian bond-elute, 10 g) and washed with methanol. The methanolic fractions were concentrated in vacuo to afford the title compound (D5).

후처리

  1. temperatureto cool
  2. washwashed with methanol
  3. concentrationThe methanolic fractions were concentrated in vacuo

출처 및 근거

ORD 기록
ord-7f326dce32854931a218dc9a33e9d305
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207331B2

반응 노트

불러오는 중…