Sodium Cyanide → 5-Bromopyrimidine-2-carbonitrile

HRID 222653

반응식

HRID 222653 반응식
[C-:1]#[N:2].[Na+].[Br:4][C:5]1[CH:6]=[N:7][C:8](Cl)=[N:9][CH:10]=1>CN(C)C=O.O>[Br:4][C:5]1[CH:6]=[N:7][C:8]([C:1]#[N:2])=[N:9][CH:10]=1

참가 물질

5

반응물 2

HCID 8929Sodium CyanideHCID 6066655-Bromo-2-chloropyrimidine

생성물 1

HCID 6865465-Bromopyrimidine-2-carbonitrile

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Sodium cyanide (2.30 g, 46.6 mmol) was dissolved in dimethylformamide (60 ml) and treated with 5-bromo-2-chloropyrimidine (6.0 g, 31.1 mmol). The resulting mixture was stirred at room temperature for 18 hours, diluted with water and extracted with dichloromethane. The dichloromethane extracts were combined, washed with water, dried (magnesium sulphate), filtered and concentrated in vacuo. The crude product was purified by column chromatography eluting with a mixture of ethyl acetate:hexane (1:4) to afford the title compound (D38).

후처리

  1. extractionextracted with dichloromethane
  2. washwashed with water
  3. dry with materialdried (magnesium sulphate)
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo
  6. customThe crude product was purified by column chromatography
  7. washeluting with a mixture of ethyl acetate:hexane (1:4)

출처 및 근거

ORD 기록
ord-a84687f9b7854a1796316c632dea7ae1
출처 데이터셋
uspto-grants-2012_06
특허 번호
US08207331B2

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