Acrylonitrile → Piperidine-1-propylamine

HRID 2226620노트

반응식

HRID 2226620 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:7](#[N:10])[CH:8]=[CH2:9].N1(C(C)C#N)CCCCC1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(O)C.O1CCCC1>[NH2:10][CH2:7][CH2:8][CH2:9][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

7

반응물 4

HCID 7855AcrylonitrileHCID 8082PiperidineHCID 129574652-(Piperidin-1-yl)propanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 19049Piperidine-1-propylamine

시약·촉매·용매 2

HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

Reaction of piperidine (Aldrich, 8.4 g, 100 mmol) with acrylonitrile (7.96 g, 150 mmol) in ethanol (25 mL), reduction of the resulting piperidinopropionitrile with lithium aluminum hydride (5 g, 125 mmol) in tetrahydrofuran (150 mL), work-up and distillation under reduced pressure as described for Example 3 gave the title compound. Yield: 3 g (21%); bp. 65°-66° (6 Torr); [lit. bp. 110°-115° C. (31 Torr), J. Corse et al., J. Amer. Chem. Soc., 68, 1911 (1946)].

후처리

  1. distillationdistillation under reduced pressure

출처 및 근거

ORD 기록
ord-f036c09dfb994ae8973e66bcfb8ebc39
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05349063

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