Sodium Iodide → Ethyl 4-iodo-3-oxobutanoate

HRID 2226657노트

반응식

HRID 2226657 반응식
[I-:1].[Na+].Cl[CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]>CC(C)=O.CCCCC.O.C(OCC)(=O)C>[I:1][CH2:4][C:5](=[O:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]

참가 물질

7

반응물 2

HCID 5238Sodium Iodide2회HCID 69484Ethyl 4-chloroacetoacetate

생성물 1

HCID 12779728Ethyl 4-iodo-3-oxobutanoate

시약·촉매·용매 4

HCID 180Acetone용매HCID 962Water용매HCID 8003Pentane용매HCID 8857Ethyl Acetate용매

반응 조건

온도
0 °C

실험 절차

Sodium iodide (228 g) was dissolved in acetone (135 mL) and cooled to 0° C. 4-chloro-3-oxobutanoic acid, ethyl ester (5.0 g) was added to the sodium iodide solution and the mixture was stirred at 0° C. for 20 minutes. It was diluted with pentane (135 mL) and water (135 mL). The reaction mixture was diluted with ethyl acetate and washed with water, brine and dried over anhydrous sodium sulfate to give an intermediate (4-Iodo-3-oxobutanoic acid, ethyl ester; 6.2 g yield).

후처리

  1. washwashed with water, brine
  2. dry with materialdried over anhydrous sodium sulfate
  3. customto give

출처 및 근거

ORD 기록
ord-31734ba6240e48b099acd4eb53137c50
출처 데이터셋
uspto-grants-1994_09
특허 번호
US05349069

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