Phenethyl bromide → HCID 6483409, 화합물

HRID 2227466노트

반응식

HRID 2227466 반응식
[CH3:1][S:2][C:3]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)[O:5][N:4]=1.[C:17]1([CH2:23][CH2:24]Br)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH3:1][S:2][C:3]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:24][CH2:23][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:12][CH:11]=2)[O:5][N:4]=1

참가 물질

5

반응물 3

HCID 7666Phenethyl bromideHCID 11430Potassium CarbonateHCID 135525222HCID 135525222, 화합물

생성물 1

HCID 6483409HCID 6483409, 화합물수율 80%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Equimolecular amounts of (III), 2-phenyl-ethyl bromide and K2CO3 were refluxed in acetone for 48 h. The mixture was concentrated to small volume and shaken with diethyl ether and water. The ether phase was washed with 2 M NaOH, then with water, evaporated to dryness and the residue was recrystallized from ethanol. The title product was obtained in an 80% yield (abbreviation ON-6), m.p. 93-940° C. (ethanol); IR (KBr) 2227 (CN) cm1; 1H NMR (CDCl3) (δ, ppm) 2.66 (s, 3H, SCH3); 3.14 (t, 2H, CH2—Ph); 4.26 (t, 2H, O—CH2); 7.30 (m, 5H, arom.); 6.99-8.00 (m, 4H, arom.).

후처리

  1. concentrationThe mixture was concentrated to small volume
  2. washThe ether phase was washed with 2 M NaOH
  3. customwith water, evaporated to dryness
  4. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-256d619071ed4830aebb4e85f484e208
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06414004B1

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