Methylamine → HCID 178482440, 화합물

HRID 2227527노트

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HRID 2227527 반응식
[CH3:1][N:2](C)[C:3]1[O:4][CH:5]([CH:9]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][C:18]=3[O:20][CH3:21])[NH:13][CH:12]=2)[CH3:10])[C:6](=[O:8])[N:7]=1.CN>>[CH3:21][O:20][C:18]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:19]=1[C:11]([CH:9]([CH:5]1[O:4][C:3]([NH:2][CH3:1])=[N:7][C:6]1=[O:8])[CH3:10])=[CH:12][NH:13]2

참가 물질

3

반응물 2

HCID 6329Methylamine2회HCID 18473977HCID 18473977, 화합물

생성물 1

HCID 178482440HCID 178482440, 화합물수율 67.1%

실험 절차

2-dimethylamino-5-[1-(4-methoxyindol-3-yl)ethyl]-2-oxazolin-4-one (50 mg) was added to methylamine (5 ml). The mixture was refluxed for 5 hours and additional methylamine (5 ml) was added. The whole was further refluxed for 2.5 hours. The-methylamine was distilled off to give a residue, which was subjected to silica gel chromatography. Elution with hexane-acetone (1:1) provided the titled compound (32 mg).

후처리

  1. temperatureThe mixture was refluxed for 5 hours
  2. temperatureThe whole was further refluxed for 2.5 hours
  3. distillationThe-methylamine was distilled off
  4. customto give a residue, which
  5. washElution with hexane-acetone (1:1)

출처 및 근거

ORD 기록
ord-c6066102b7c04af98708a751271ebd85
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06414003B1

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