Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyruvic Acid → 2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl 2-oxopropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyruvic Acid | HCID 1060 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 2,6-dimethyl-4-(1-phenyl-1H-pyrazol-3-yl) aminophenol | HCID 19927913 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2,6-Dimethyl-4-(1-phenyl-1H-pyrazol-3-yl)aminophenyl 2-oxopropanoate | HCID 19927936 | — |
반응 단계
1,1'-carbonyldiimidazole (4.9 g) was added batchwise to pyruvic acid (2.6 g) in dichloromethane (100 ml), and after 0.5 hours 2,6-dimethyl-4-(1-phenyl-1H-pyrazol-3-yl) aminophenol (2.8 g) was added. The mixture was left for 16 hours, then evaporated, and the residue was chromatographed (silica, dichloromethane) to give, after crystallisation (hexane/ethyl acetate), the title product (1.0 g) mp 123°-125°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428044 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-53b23d7d80234aec8d63a40301135afd |
| 출처 메모 | uspto-grants-1995_06 |