Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropanecarboxaldehyde → (S,E)-N-(cyclopropylmethylene)-2-methylpropane-2-sulfinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropanecarboxaldehyde | HCID 123114 | — |
| 반응물 | tert-Butylsulfinamide, (S)-(-)- | HCID 11355477 | — |
| 촉매 | Copper Sulfate | HCID 24462 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S,E)-N-(cyclopropylmethylene)-2-methylpropane-2-sulfinamide | HCID 67007580 | 95% |
반응 단계
The title compound was prepared according to a general procedure described by G. Liu, D. A. Cogan, T. D. Owens, T. P. Tang, and J. A. Ellman J. Org. Chem. 1999, 64, 1278: A mixture of cyclopropanecarboxaldehyde (35.0 g, 0.5 mol), (S)-(−)-2-methyl-2-propanesulfinamide (30 g, 0.25 mol) and anhydrous CuSO4 (120 g, 0.75 mol) in CH2Cl2 (1500 mL) was stirred at room temperature overnight. The reaction mixture was filtered and evaporated to give the title compound (39 g, yield 95%), which was used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08207347B2 |
| 출처 데이터셋 | uspto-grants-2012_06 |
| ORD ID | ord-33e946aeab894b1388f17fba0ad828fe |
| 출처 메모 | uspto-grants-2012_06 |