Water → N-(1-Benzylpiperidin-4-yl)acetamide

HRID 2228

반응식

HRID 2228 반응식
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1.C(N(CC)CC)C.O>ClCCl>[C:1]([NH:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:7]1)(=[O:3])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 4158521-Benzyl-4-piperidylamine

생성물 1

HCID 12641850N-(1-Benzylpiperidin-4-yl)acetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Acetyl chloride (3.95 ml) was added dropwise to a stirred solution of 4-amino1-benzylpiperidine (10.0 g) and triethylamine (7.7 ml) in dry dichloromethane (100 ml) at 4° C. The mixture was allowed to reach ambient temperature and stirred for 16 hours. Water was then added, the organic phase separated and dried (MgSO4), and removal of the solvent by evaporation gave 4-acetylamino-1-benzylpiperidine, 10.23 g, as a light brown solid which was used without further purification: NMR (CDCl3) δ 7.29(5H,m), 5.29(1H,b), 3.79(1H,m), 3.49(2H,s), 2.80(2H,dm), 2.12(2H,dt), 1.95(3H,s), 191(2H,dm), 1.46(2H,dq); m/e 233 (M+H)+.

후처리

  1. customto reach ambient temperature
  2. customthe organic phase separated
  3. customdried
  4. custom(MgSO4), and removal of the solvent
  5. customby evaporation

출처 및 근거

ORD 기록
ord-53468aff36b74b69af45a0218b9d4c73
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728701

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