Methanol → Methyl 3-methyl-5-phenylbenzoate

HRID 2228019노트

반응식

HRID 2228019 반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=1)[C:5]([OH:7])=[O:6].[CH3:17]O>OS(O)(=O)=O>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:10]=1)[C:5]([O:7][CH3:17])=[O:6]

참가 물질

4

반응물 2

HCID 887MethanolHCID 184745993-Methyl-5-phenylbenzoic acid

생성물 1

HCID 11379139Methyl 3-methyl-5-phenylbenzoate수율 94%

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

A solution of 3-methyl-5-phenylbenzoic acid (3.5 g; 16.5 mmol) and concentrated H2SO4 (30 drops) in methanol (25 ml) was heated at reflux overnight. After evaporation to dryness, the residue was extracted with ether. The organic phase was evaporated and purified by flash chromatography eluting with petroleum ether/ethyl acetate (90/10) to give methyl 3-methyl-5-phenylbenzoate as an oil. Yield=94%.

후처리

  1. temperatureat reflux overnight
  2. customAfter evaporation to dryness
  3. extractionthe residue was extracted with ether
  4. customThe organic phase was evaporated
  5. custompurified by flash chromatography
  6. washeluting with petroleum ether/ethyl acetate (90/10)

출처 및 근거

ORD 기록
ord-48ddedae0c894ffa8b2c2b9042f7762e
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06414145B1

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