2-Pyridinemethanol,a-(4-nitrophenyl)- → (4-Aminophenyl) (2-pyridyl)methanol
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1참가 물질
3
실험 절차
In ethanol (50 ml) was dissolved (4-nitrophenyl)—(2-pyridyl)methanol (2.30 g), and to the mixture was added dried 10% palladium on carbon (0.12 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 19 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from ethyl acetate-hexane to give (4-aminophenyl) (2-pyridyl)methanol (1.90 g) as pale yellow crystals.
후처리
- additionto the mixture was added
- dry with materialdried 10% palladium on carbon (0.12 g)
- filtrationThe palladium was filtered off
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from ethyl acetate-hexane
출처 및 근거
- ORD 기록
- ord-38fdd0d360d448d2b043a2f9b758a7fe
- 출처 데이터셋
- uspto-grants-2002_07
- 특허 번호
- US06413947B1
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