Hydroquinone → 1-(2-Methacryloyloxyethyl)indole

HRID 2228369노트

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HRID 2228369 반응식
Cl[CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1.[C:13]([O-:18])(=[O:17])[C:14]([CH3:16])=[CH2:15].[K+].[I-].[K+].C1(C=CC(O)=CC=1)O>CN(C)C=O>[C:13]([O:18][CH2:2][CH2:3][N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5]1)(=[O:17])[C:14]([CH3:16])=[CH2:15]

참가 물질

6

반응물 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 108992601-(2-chloroethyl)-1H-indoleHCID 23667354Potassium methacrylate

생성물 1

HCID 184697791-(2-Methacryloyloxyethyl)indole수율 78.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Next, to a flask of 200 ml capacity fitted with a stirrer and cooling tube, there were introduced 15.4 g of 1-(2-chloroethyl)indole, 21.3 g of potassium methacrylate, 7.1 g of potassium iodide, 40 ml of N,N-dimethyl formamide and a small amount of hydroquinone. The mixture was heated to 100° C. and was stirred for 2.5 hours. After completion of the reaction, the insoluble material was removed by filtration, and concentration was performed under reduced pressure. This reaction mixture was then purified by column chromatography using silica gel, to obtain 15.5 g of 1-(2-methacryloyloxyethyl)indole.

후처리

  1. customNext, to a flask of 200 ml capacity fitted with a stirrer
  2. temperaturecooling tube
  3. customAfter completion of the reaction
  4. customthe insoluble material was removed by filtration, and concentration
  5. customThis reaction mixture was then purified by column chromatography

출처 및 근거

ORD 기록
ord-635e3ff93a264caeb7583e02896f6427
출처 데이터셋
uspto-grants-2002_07
특허 번호
US06416939B1

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